[clause: A],相比之下,[clause: B]
和 / 与 + [noun] + 相比,[clause]
相比之下 sets a second thing against one just described: "by comparison", "in contrast". The first clause describes A; 相比之下 opens the next clause, which describes B in the light of A. 之 is a written "it" pointing back at A, so nothing follows 相比之下 except the comma.
The second clause usually carries a degree word – 多了, 得多, 一些, 更 – because the comparison has been set up already.
相比之下 already contains its comparison. To name what you're comparing with, use 和…相比 or 与…相比 instead.
It is neutral to written, and works in speech too when you're weighing two options.