Generated: This usage expresses inquiries about the degree or extent of something, often in the context of asking for more information or clarification regarding a situation or condition.
No matter how difficult it is, I will take on the challenge.
no matter how (much); howeveras どんなに...ても, どんなに...でも, etc.
Generated: This meaning indicates a sense of inevitability or determination regardless of the conditions or circumstances, often used to emphasize resilience or commitment.