[noun] + を皮切りに、[sentence] [noun] + を皮切りにして、[sentence] [noun] + を皮切りとして、[sentence]
を皮切りに goes after a noun for an event and makes it the first in a series: "starting with", "kicking off with". The rest of the sentence says what followed – more of the same, one after another, or spreading wider. It belongs to the news, reports and speeches.
The second half has to be a series or a spread, so it often carries つぎつぎ次々と, かくち各地で or ぜんこく全国に. A single thing that happened afterwards takes をきっかけに instead.
を皮切りにして and を皮切りとして mean the same as を皮切りに; として is a shade more formal.