[verb ない-form] + ことには、[negative clause] [i-adj 〜い → 〜く] + ないことには、[negative clause] [noun] / [na-adj] + でないことには、[negative clause]
ないことには means "unless": until the first thing is done, the second cannot happen. The verb takes the ない-form plus ことには, and the second half is negative too, most often "can't" or "won't know".
The first half is a precondition, so verbs like やってみる, みる見る, きく聞く and しらべる調べる are frequent there.
The result is something that can't happen yet: わからない, できない, はじまらない始まらない. A positive result, a request or an order does not fit.
A noun or a な-adjective takes でないことには, and an い-adjective くないことには. The second half follows the same rule as with a verb.