何しろ puts a reason up front as the one that settles it: "after all", "you see", "what with". It opens the clause that gives the reason, which usually ends in , or , and the result follows.
、。
After all, it was my first time, so I couldn't do it well.
、。
After all, the population is large, so everywhere is crowded.
、。
After all, the opponent is a pro, so there's no way to beat them.
The reason is one the listener can't argue with, so the result sounds natural – "no wonder".
、。
After all, he hasn't slept for three days, so no wonder he's tired.
何しろ or とにかく
, "anyway", sets other things aside to get to the point, which is often an action. 何しろ can do that too, but mostly it backs a reason.
。
Let's just go and see, anyway.
、。
We really don't have time, so please hurry.
means the same as 何しろ and is a little more casual.
Lingaku