The grammar structure 上は expresses a strong sense of resolve or obligation that follows naturally from a decision, action, or situation that has already been established. It translates to "now that…", "since…", or "as long as…" in English, and carries the nuance that once something has been decided or has occurred, one must fully commit to the consequences or follow through.
This pattern is used when the speaker feels that the situation in the first clause creates a strong reason or moral obligation to do what is stated in the second clause. The second clause typically contains expressions of determination, duty, or necessity – such as なければならない, べきだ, つもりだ, or volitional forms.
上は is a relatively formal expression, commonly found in written language, speeches, and serious conversations. In casual speech, いじょう以上は or からには are similar alternatives, with からには being slightly broader in register.
The second clause almost always expresses the speaker's will, determination, advice, or obligation – it would be unnatural to follow 上は with a statement about something outside the speaker's control.