Negation ("is not")
Seeking confirmation ("isn't it?") – rising intonation ↑
Polite variants
じゃない is the contracted form of ではない
The most basic use of じゃない is to negate nouns and な-adjectives in casual speech.
The polite equivalents are じゃないです (casual-polite) and じゃありません or ではありません (formal-polite).
With rising intonation (じゃない?), it functions like a tag question, asking the listener to confirm something.
With falling intonation, じゃない can express pleasant surprise upon recognizing or realizing something – effectively meaning "Oh, it IS...!" despite its literally negative form. This usage is especially common among female speakers.
じゃない can also gently offer an opinion or suggestion, similar to "I think it's…" or "isn't it probably…?" This is common with いい to express casual approval.