I appreciate that you are very fatigued.

I dare say you are tired.

You look very tired. You must have been working too hard.

You look tired.

You are tired, aren't you?

You must be tired, but hang on 'til 3.

You look tired.

"You must be tired after a long day." "No, not in the least."

"You must be tired after a long day." "No, not in the least."

Thank you for your work as well.

You must be tired after such a long trip.

"You seem tired lately, is everything all right?" "Oh, it's my daughter. She's become all grown up and I'm worried about all sorts of things."